Zardoya San Sebastian Rafael

Investigación

I am interested in patterns, processes and mechanisms associated to the generation of biodiversity, a central question in Evolutionary Biology. My research is focused in determining the amount and type of genetic variation linked to speciation events and its relationship to morphological and behavioral adaptation. Thus, I infer statistically robust phylogenetic frameworks and perform comparative genomics that allow me reconstructing the evolution of morphological and behavioral traits, as well as understanding the historical generation of current biogeographical patterns. I am currently focused mainly on gastropod systematics (with particular emphasis on cone snails) and base phylogenetic inferences on complete mitochondrial genome sequence data as well as nuclear markers derived from next generation sequencing technologies. To complement the above-mentioned research, I have also active research in molecular evolution. I am interested in the evolution of gene families (particularly conotoxins through comparative transcriptomics), model selection, and the causes behind incorrect phylogenetic inferences.

Miembros de grupo

Ana Herráez-Pérez (Graduate student FPI) — Cone snails comparative genomics/ transcriptomics

Publicaciones relevantes

For a full list see here

_{JJ Rondón, VA Pisarenco, JR Pardos-Blas, A Sánchez-Gracia, R. Zardoya, And J. Rozas (2024) Comparative genomic analysis of chemosensory-related gene families in gastropods. Mol. Phylogenet. Evol.  192: 107986
​S Abalde, F Crocetta, MJ Tenorio, S D'Aniello, G Fassio,  PC Rodríguez-Flores, JE Uribe, CML Afonso, M Oliverio,And R. Zardoya (2023) Hidden species diversity and mito-nuclear discordance within the Mediterranean cone snail, Lautoconus ventricosus. Mol. Phylogenet. Evol. 186: 107838
KR Johnson, IFP Owens, Global Collection Group (R. Zardoya) (2023) A global approach for natural history museum collections. Science 379: 1192-1194
A Herráez-Pérez, JR Pardos-Blas, CML Afonso, MJ Tenorio, And R. Zardoya (2023) Chromosome-level genome of the venomous snail Kalloconus canariensis: a valuable model for venomics and comparative genomics. GigaScience 12: giad075
JR Pardos-Blas, MJ Tenorio, JCG Galindo, And R. Zardoya (2022) Comparative venomics of the cryptic cone snail species Virroconus ebraeus and Virroconus judaeus. Mar. Drugs 20: 149}

_{M Recuerda, JC Illera, G Blanco, R. Zardoya, And B Milá (2021) Sequential colonization of oceanic archipelagos led to a species-level radiation in the common chaffinch complex (Aves: Fringilla coelebs).  Mol. Phylogenet. Evol.  164: 107291
S Abalde, S Dutertre, And R. Zardoya (2021) A combined transcriptomics and proteomics approach reveals the differences in the predatory and defensive venoms of the molluscivorous cone snail Cylinder ammiralis. Toxins 13: 642}

_{Y Yang, S Abalde, CLM Afonso, MJ Tenorio, N Puillandre, J Templado, And R. Zardoya (2021) Mitogenomic phylogeny of mud snails of the mostly Atlantic/Mediterranean genus Tritia (Gastropoda: Nassariidae). Zool. Scri. 50: 571-591
JR Pardos-Blas, I Irisarri, S Abalde, CML Afonso, MJ Tenorio, And R. Zardoya (2021) The genome of the venomous snail Lautoconus ventricosus sheds light on the origin of conotoxin diversity. Gigascience 10: giab037}

_{R. Zardoya (2021) Quest for the Best Evolutionary Model. J. Mol. Evol. 89: 146–150}

_{I. Irisarri, J.E. Uribe, D.J. Eernisse, And R. Zardoya (2020) A mitogenomic phylogeny of chitons (Mollusca: Polyplacophora). BMC Evol. Biol. 20: 1-15}

_{​M.J. Tenorio, S. Abalde, J.R. Pardos-Blas, And R. Zardoya (2020) Taxonomic revision of West African cone snails (Gastropoda: Conidae) based upon mitogenomic studies: implications for conservation. European J. Taxon. 663}

_{S. Abalde, M.J. Tenorio, C.M.L. Afonso, And R. Zardoya (2020) Comparative transcriptomics of the venoms of continental and insular radiations of West African cones. Proc. Royal Soc. B 287: 20200794}

_{R. Zardoya (2020) Recent advances in understanding mitochondrial genome diversity. F1000 Res. 9: 270}

_{JR Pardos-Blas, I. Irisarri, S. Abalde, M.J. Tenorio, And R. Zardoya (2019) Conotoxin diversity in the venom gland transcriptome of the Magician’s cone, Pionoconus magus.  Marine drugs 17: 553}

_{​J.E. Uribe, I. Irisarri, J. Templado, And R. Zardoya (2019) New patellogastropod mitogenomes help counteracting long-branch attraction in the deep phylogeny of gastropod mollusks.  Mol. Phylogenet. Evol. 133: 12-23​}

_{S. Abalde, M.J. Tenorio, J.E. Uribe, And R. Zardoya (2019) Conidae phylogenomics and evolution. Zool. Scri. 48: 194-214}

_{​S. Abalde, M.J. Tenorio, C.M.L. Afonso, And R. Zardoya (2018) Conotoxin diversity in Chelyconus ermineus (Born, 1778) and the convergent origin of piscivory in the Atlantic and Indo-Pacific cones. Genome Biol. Evol. 10: 2643-2662}

_{S. Abalde, M.J. Tenorio, C.M.L. Afonso, J.E. Uribe, A.M. Echeverry, And R. Zardoya (2017) Phylogenetic relationships of cone snails endemic to Cabo Verde based on mitochondrial genomes. BMC Evol. Biol. 17: 231}

_{​J.E. Uribe, And R. Zardoya (2017) Revisiting the phylogeny of Cephalopoda using complete mitochondrial genomes. J. Molluscan. Stud. 83: 133-144}

_{​J.E. Uribe, N. Puillandre, And R. Zardoya (2017) Beyond Conus: Phylogenetic relationships of Conidae based on complete mitochondrial genomes. Mol. Phylogenet. Evol. 107: 142-151}

_{​J.E. Uribe, S.T. Williams, J. Templado, B. Buge, And R. Zardoya (2017) Phylogenetic relationships of Mediterranean and North-East Atlantic Cantharidinae and notes on Stomatellinae (Vetigastropoda: Trochidae). Mol. Phylogenet. Evol.  107: 64-79}

_{​J.E. Uribe, Y. Kano, J. Templado And R. Zardoya (2015) Mitogenomics of Vetigastropoda: insights into the evolution of pallial symmetry. Zool. Script.  45: 145-159}

_{D. Osca, J. Templado And R. Zardoya (2015) Caenogastropod mitogenomics. Mol. Phylogenet. Evol. 93: 118-128}

_{E Kornobis, L Cabellos, F Aguilar, C Frías-López, J Rozas, J Marco And R. Zardoya (2015) TRUFA: a user-friendly web server for de novo RNA-seq analysis using cluster computing. Evol. Bioinfor. 11: 97}

_{E.G. Gonzalez, I. Cerón-Souza, J.A. Mateo And R. Zardoya (2015) Island survivors: population genetic structure and demography of the critically endangered giant lizard of La Gomera, Gallotia bravoana. BMC genetics 15: 121}

_{O. Rican, L. Pialek, R.Zardoya, I. Doadrio, And J. Zrzavy (2013) Biogeography of the Mesoamerican Cichlidae (Teleostei: Heroini): colonization through the GAARlandia land bridge and early diversification J. Biogeo. 40: 579-593
F. Abascal And R. Zardoya (2013) Evolutionary analyses of gap junction protein families Biochimica et Biophysica Acta (BBA)-Biomembranes 1828: 4-14
F. Abascal And R. Zardoya (2012) LRRC8 proteins share a common ancestor with pannexins, and may form hexameric channels involved in cell‐cell communication BioEssays 34: 551-560
M.T. Cabria, J.R. Michaux, B.J. Gómez-Moliner, D. Skumatov, T. Maran, P. Fournier, J.L. De Luzuriaga, And R. Zardoya (2011) Bayesian analysis of hybridization and introgression between the endangered european mink (Mustela lutreola) and the polecat (Mustela putorius) Mol. Ecol. 20: 176-190
I. Irisarri, M. Vences, D. San Mauro, F. Glaw, And R. Zardoya (2011) Reversal to air-driven sound production revealed by a molecular phylogeny of tongueless frogs, family Pipidae BMC Evol. Biol. 11: 114
F. Abascal, R. Zardoya, M.J. Telford (2010) TranslatorX: multiple alignment of nucleotide sequences guided by amino acid translations Nucleic Acids Res. 38 Suppl: W7-W13
A.P. Hendry, L.G. Lohmann, E. Conti, J. Cracraft, K.A. Crandall, D.P. Faith, C. Häuser, C.A. Joly, K. Kogure, A. Larigauderie, S. Magallón, C. Moritz, S. Tillier, R. Zardoya, A.H. Prieur-Richard, B.A. Walther, T. Yahara And M.J. Donoghue. (2010) Evolutionary biology in biodiversity science, conservation, and policy: a call to action. Evolution 64:1517-1528
E.G. Gonzalez, M. Genovart, D. Oro, R. Zardoya And J. Juste (2009) Polymorphic microsatellite markers for the critically endangered Balearic shearwater, Puffinus mauretanicus Mol. Ecol. Res. 9: 1044-1046
C. Hernández-Sánchez, A. Mansilla, F. De Pablo And R. Zardoya (2008) Evolution of the insulin receptor family and of receptor isoform expression in vertebrates Mol. Biol. Evol. 25: 1043-1053
R. L. Cunha, M. J. Tenorio, C. Afonso, R. Castilho And R. Zardoya (2008) Replaying the tape: replicated evolutionary patterns in Cape Verde Conus Mol. Ecol. 17: 885-901
E. Albert, R. Zardoya And M. García París (2007) Phylogeographic and speciation patterns in subterranean worm lizards of the genus Blanus (Amphisbaenia: Blanidae) Mol. Ecol. 16: 1519-1531
F. Abascal, D. Posada And R. Zardoya (2007) MtArt: a new model of amino acid replacement for Arthropoda Mol. Biol. Evol. 24: 1-5
F. Abascal, D. Posada, R. Knight And R. Zardoya (2006) Parallel evolution of the mitochondrial genetic code in insects PLoS Biology. 4: 711-718
M.T. Cabría, J. Rubines, B. Gómez-Moliner And R. Zardoya (2006) On the phylogenetic position of a rare Iberian endemic mammal, the Pyrenean desman (Galemys pyrenaicus) Gene. 375: 1-13
L. Rüber, R. Britz And R. Zardoya (2006) Molecular phylogenetics and evolutionary diversification of labyrinth fishes (Perciformes; Anabantoidei) Syst. Biol. 55: 374-397
D. San Mauro, D.J. Gower, R. Zardoya And M. Wilkinson (2006) A hotspot of gene rearrangement by tandem duplication and random loss in the vertebrate mitochondrial genome Mol. Biol. Evol. 23: 227- 234
T. Atarhouch, L. Rüber, E. G. González, E. Albert, M. Rami, A. Dakkak, And R. Zardoya (2006) Signature of an early genetic bottleneck in a population of Moroccan sardines (Sardina pilchardus) Mol. Phylogenet. Evol. 39: 373-383
R. Zardoya (2005) Phylogeny and evolution of the Major Intrinsic Protein family Biol. Cell. 97: 397-414
R. L. Cunha, R. Castilho, L. Rüber, And R. Zardoya (2005) Patterns of cladogenesis in the venomous marine gastropod genus Conus from the Cape Verde Islands Syst. Biol.. 54: 634-650
F. Abascal, R. Zardoya And D. Posada (2005) ProtTest: Selection of best-fit models of protein evolution Bioinformatics. 21: 2104-2105
L. Rüber And R. Zardoya (2005) Rapid cladogenesis in marine fishes revisited Evolution. 59: 1119-1127
D. San Mauro, M. Vences, M. Alcobendas, R. Zardoya And A. Meyer (2005) Initial Diversification of Living Amphibians Predated the Breakup of Pangaea. Am. Nat. 165: 590-599
F.J. Cabrero-Sañudo and R. Zardoya (2004) Phylogenetic relationships of Iberian Aphodiini (Coleoptera: Scarabaeidae) based on morphological and molecular data. Mol. Phylogenet. Evol. 31: 1084-1100
L. Rüber, R. Britz, H.H. Tan, P.K.L. Ng And R. Zardoya (2004) Evolution of mouthbrooding and life-history correlates in the fighting fish genus Betta. Evolution 58: 798-813
C. Grande, J. Templado, J.L. Cervera And R. Zardoya (2004) Molecular phylogeny of Euthyneura (Mollusca: Gastropoda). Mol. Biol. Evol. 21: 303-313
A. Meyer And R. Zardoya (2003) Recent Advances in the (Molecular) Phylogeny of Vertebrates. Ann. Rev. Ecol. Syst. 34:311-338}

Proyectos

_{• Adaptive evolution in insular radiations of cone snails (Gastropoda: Conidae) using data from high quality complete genomes}  

_{Grant: PID2022-138477NB-C21}

_{Funding Agency: Ministry of Science, Innovation and Universities-AEI of Spain}

_{Duration: 01/09/2023 - 31/08/207}

_{Amount (€): 243.750}

_{PI: Zardoya, R.} 

_{• The genomics of adaptation in evolutionary radiations}

_{Grant: PID2019-103947GB-C22}

_{Funding Agency: Ministry of Science and Innovation-AEI of  Spain)}

_{Duration: 01/06/2020 - 31/05/2023}

_{Amount (€): 222.640}

_{PI: Zardoya, R.} 

_{• Comparative genomics and adaptation in the study of a radiation in Macaronesian Islands: the marine snail Conus of Cabo Verde and its conotoxins as a model system.}  

_{Grant: CGL2016 - 75255-C2-1-P}  

_{Funding Agency: Ministry of Economy, Industry and Competitiveness of Spain}

_{Duration: 30/12/2016 - 29/12/2019}

_{Amount (€): 189 970}

_{PI: Zardoya, R.} 

_{•  Understanding the molecular basis of island radiations: Evolutionary study of conotoxins in marine snails Africonus of Cape Verde using transcriptomics.}  

_{Grant: CGL2013-45211-C2-2-P}

_{Funding Agency: Ministry of Economy, Industry and Competitiveness of Spain}

_{Duration: 30/01/2014 - 29/12/2016}   

 _{Amount (€): 130 000}

_{PI: Zardoya, R}

 _{• Molecular phylogeny of gastropod mollusks based on complete mitochondrial genomes.}  

_{Grant: CGL2007 - 60954}

_{Funding Agency: Ministry of Science & Technology}

_{Duration: 01/10/2007 - 31/12/2010}

_{Amount (€): 225 060}

_{PI: Zardoya, R}